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Published Papers on Amdoxovir (DAPD)

Amdoxovir (DAPD), RFS Pharma's lead drug candidate,
is currently undergoing late Phase II clinical trials.

Please visit www.pubmed.gov for abstracts
and/or full text versions of the articles below.

Preclinical

Hernandez-Santiago BI, Okikhod A, Fromentin E, Hurwitz SJ, Schinazi RF. Cellular pharmacology of 9-(b-D-1,3-dioxolan-4-yl)guanine (DXG) and its lack of drug interactions with zidovudine in primary human lymphocytes. Antivir. Chem. Chemother. 18(6): 343-346, 2007.
Abstract available on PubMed

Menne S, Asif G, Narayanasamy J, Butler SD, George AL, Hurwitz SJ, Schinazi RF, Chu CK, Cote PJ, Gerin JL, Tennant BC. Antiviral effect of orally administered (-)-beta-D-2-aminopurine dioxolane in woodchucks with chronic woodchuck hepatitis virus infection. Antimicrob Agents Chemother. 51(9): 3177-84, 2007 Sep.
Full Text available in PubMed Central

Hurwitz SJ, Asif G, Kivel NM, Schinazi RF. Development of an optimized dose for coformulation of zidovudine with drugs that select for the K65R mutation using a population pharmacokinetic and enzyme kinetic simulation model. Antimicrob Agents Chemother. 52(12): 4241-4250, 2008 Dec.
Full Text available in PubMed Central

Clinical

Thompson MA, Kessler HA, Eron JJ Jr, Jacobson JM, Adda N, Shen G, Zong J, Harris J, Moxham C, Rousseau FS, DAPD-101 Study Group. Short-term safety and pharmacodynamics of amdoxovir in HIV-infected patients. AIDS. 19(15): 1607-15, 2005 Oct 14.
Abstract available on PubMed

Gripshover BM, Ribaudo H, Santana J, Gerber JG, Campbell TB, Hogg E, Jarocki B, Hammer SM, Kuritzkes DR, A5118 Team. Amdoxovir versus placebo with enfuvirtide plus optimized background therapy for HIV-1-infected subjects failing current therapy (AACTG A5118). Antivir Ther. 11(5): 619-23, 2006.
Abstract available on PubMed

Margolis DM, Mukherjee AL, Fletcher CV, Hogg E, Ogata-Arakaki D, Petersen T, Rusin D, Martinez A, Mellors JW. The use of beta-D-2,6-diaminopurine dioxolane with or without mycophenolate mofetil in drug-resistant HIV infection. AIDS. 21(15): 2025-32, 2007 Oct 1.
Abstract available on PubMed